Illustration from Welcome to PlatinumCRISPr
PlatinumCRISPr provides next-generation CRISPR guide design and implements correct RNA folding and other rules derived from Haussmann et al.(2024). The PlatinumCRISPr Web-Server integrates these structure based guide RNA assessment with off-target evaluation to support gene editing experiments in cells and model organisms.
- Select correctly folded sgRNAs (Unique to PlatinumCRISPr)
- Find potential off-target sites
- Visualize crRNA-tracrRNA folding (Unique to PlatinumCRISPr)
- KO Guide: guide to generate knock-outs in cell lines and model organsims
- Ensembl integration
PlatinumCRISPr directly employs Ensembl for:
- Gene model visualisation
- Gene sequence retrieval
- Region-based guide selection
Retrieve any gene sequence by symbol or Ensembl ID, select custom genomic sequences, and feed them directly into the sgRNA scanning workflow.
